IMMUNITY AND BACTERIAL BIOFILMS: CURRENT STATUS OF THE MATTER (LITERATURE REVIEW)

The problem of prevention and treatment infectious diseases in practical health care is one the most difficult, unsolved priority ones. At same time, fact biofilm formation by microorganisms-causative agents has already been proved, which leads to an increase resistance pathogens infectious-inflammatory antibacterial drugs, chronization process, atypical course disease. results numerous studies have shown relationship between immune system bacterial biofilms. effect links humoral cellular immunity on matrix biofilms or some its components described. Neutrophils, that play a key role phagocytosis rank first antibiofilm immunity. However, it polysaccharide reduces inhibiting phagocytic clearance bacteria. Bacteria become able use many protective reactions system, designed fight with microorganisms for their own purposes development, growth, nutrition. For example, lysozyme enhanced adhesion S. aureus surface, triggering formation. Several destruction when exposed blood serum. Other demonstrated activation complement presence biofilm.